1. Hardware requirements: The program can be executed on any system with a programmable graphics card equipped with > 1GB of memory. It has been evaluated with Intel(R) Core(TM)2 Duo CPU GeForce GT220M GPU (laptop), Intel(R) Core(TM)2 Duo E7500 2.936GHz GeForce GT240 GPU (desktop), and Mac OS X High Sierra (10.13) 2. Software requirements: Both for Mac OS (>= 10.13) and MS Windows (>= 10, 64 bits), uncompress the executable program and run it. On Linux, the pre-compiled executable programs have been linked using Ubuntu 16.04, gcc (ubuntu 5.4.0) and Nvidi Driver Version 384.130 (OpenGL > 4.0). 3. Datasets They must be in DICOM or NIfTI format.